Journal
DOSE-RESPONSE
Volume 19, Issue 1, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1559325821998136
Keywords
serotonin; cervical cord injury; neuromodulation; functional rehabilitation
Funding
- Hong Kong Polytechnic University [H-ZG4 W]
- Hong Kong Innovation and Technology Fund [ITS/276/17]
- Telefield Charitable Fund [ZH3 V]
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This study investigated the dose-response of Buspirone treatment on reaching and grasping function in cervical cord injured rats, showing that the lowest dose group had the best performance in reaching scores and grip strength.
Buspirone, widely used as a neuropsychiatric drug, has also shown potentials for motor function recovery of injured spinal cord. However, the optimum dosages of such treatment remain unclear. In this study, we investigated the dose-response of Buspirone treatment on reaching and grasping function in cervical cord injured rats. Seventeen adult Sprague-Dawley rats were trained to reach and grasp sugar pellets before a C4 bilateral dorsal column crush injury. After 1 week post-injury, the rats were divided into 3 groups to receive 1 of 3 different dosages of Buspirone (i.p., 1 dose/day: 1.5, n = 5; 2.5, n = 6 and 3.5 mg/kg b.w., n = 6). Forelimb reaching and grip strength test were recorded once per week, within 1 hour of Buspirone administration for 11 weeks post-injury. Different dose groups began to exhibit differences in reaching scores from 4 weeks post-injury. From 4-11 weeks post-injury, the reaching scores were highest in the lowest-dose group rats compared to the other 2 dose groups rats. Average grip strength was also found higher in the lowest-dose rats. Our results demonstrate a significant dose-dependence of Buspirone on the recovery of forelimb motor functions after cervical cord injury with the best performance occurring at the lowest dose tested.
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