Journal
RSC ADVANCES
Volume 11, Issue 1, Pages 160-163Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra08998b
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Funding
- National Natural Science Foundation of China [51103023, 91833304, 61761136013]
- NSF of Jiangsu Province [XYDXX-026]
- Natural Science Foundation of the Jiangsu Higher Education Institutions [19KJB150006]
- Science and Technology Development Fund, Macao SAR [FDCT-0044/2020/A1, FDCT-091/2017/A2, FDCT-014/2017/AMJ]
- UM's research fund [MYRG2018-00148-IAPME]
- Natural Science Foundation of China [91733302, 61935017]
- Natural Science Foundation of Guangdong Province, China [2019A1515012186]
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2RDNTPA, a novel acceptor-donor-acceptor type molecule, demonstrates excellent optical properties suitable for fluorescence imaging of living cancer cells.
A novel acceptor-donor-acceptor type molecule, namely 2-triphenylamine-1,3-dia[2-(3-ethyl-4-oxo-thiazolidin-2-ylidene)-malononitrile] (2RDNTPA), is designed and synthesized. 2RDNTPA exhibits a large Stokes shift of 244 nm and red fluorescence emission of 629 nm with a decent photoluminescence quantum yield of 13%. Furthermore, as a potential red fluorescent dye, 2RDNTPA can be applied in fluorescence imaging of living cancer cells (HepG2) with negligible cytotoxicity and a half maximal inhibitory concentration much more than 100 mu M.
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