Journal
INFECTIOUS DISEASE MODELLING
Volume 6, Issue -, Pages 169-182Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.idm.2020.12.001
Keywords
MSV; Eco-epidemiological model; Optimal control theory; Numerical simulation; Cost-effectiveness analysis
Funding
- PAUISTI
- UoG
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This study formulated an optimal deterministic eco-epidemiological model to combat maize streak virus (MSV) and determined that the combination of prevention and quarantine is the most cost-effective strategy. The findings emphasize the importance of integrated control interventions to stop the spread of MSV in maize population.
In this paper we formulated and analyzed an optimal deterministic eco-epidemiological model for the dynamics of maize streak virus (MSV) and examine the best strategy to fight maize population from maize streak disease (MSD). The optimal control model is developed with three control interventions, namely prevention (u(1)), quarantine (u(2)) and chemical control (u(3)). To achieve an optimal control strategy, we used the Pontryagin's maximum principle obtain the Hamiltonian, the adjoint variables, the characterization of the controls and the optimality system. Numerical simulations are performed using Forward-backward sweep iterative method. The findings show that each integrated strategy is able to mitigate the disease in the specified time. However due to limited resources, it is important to find a cost-effective strategy. Using Incremental Cost-Effectiveness Ratio(ICER) a cost-effectiveness analysis is investigated and determined that the combination of prevention and quarantine is the best cost-effective strategy from the other integrated strategies. Therefore, policymakers and stakeholders should apply the integrated intervention to stop the spread of MSV in the maize population. (c) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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