Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection

Burn wound is usually associated by antibiotic-resistant Pseudomonas aeruginosa infection that worsens and complicates its management. An effective approach is to use natural antibiotics such as cinnamon oil as a powerful alternative. This study aims to investigate topical nanostructured lipid carrier (NLC) gel loaded cinnamon oil for Pseudomonas aeruginosa wound infection. A 2(4) full factorial design was performed to optimize the formulation with particle size 108.48 +/- 6.35 nm, zeta potential -37.36 +/- 4.01 mV, and EE% 95.39 +/- 0.82%. FTIR analysis revealed no excipient interaction. Poloxamer 407 in a concentration 20% w/w NLC gel was prepared for topical application. Drug release exhibited an initial burst release in the first five hours, followed by a slow, sustained release of up to five days. NLC-cinnamon gel has a significant ability to control the drug release with the lowest minimum inhibitory concentration again P. aeruginosa compared to other formulations (p < .05). In vivo study also showed NLC-cinnamon gel effectively healed the infected burned wound after a six-day treatment course with better antibacterial efficacy in burned animal models. Histological examination ensured the tolerability of NLC-cinnamon gel. The results suggest that nanoparticle-based cinnamon oil gel is a promising natural product against antibiotic-resistant strains of P. aeruginosa in wound infection.

Automated summary

The study investigated the use of nanostructured lipid carrier gel loaded with cinnamon oil for treating Pseudomonas aeruginosa infection in burn wounds. Results showed significant ability to control drug release and a lower minimum inhibitory concentration for treating infected burn wounds effectively. This nanoparticle-based cinnamon oil gel shows promise as a natural product against antibiotic-resistant strains of P. aeruginosa in wound infection.