4.0 Article

Reaction of Pyrrolo[2,1-c][1,4]oxazine-1,6,7-triones with 3-(Arylamino)-5,5-dimethylcyclohex-2-en-1-ones. Synthesis of Spiro[indole-3,2′-pyrroles]

Journal

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 57, Issue 1, Pages 13-19

Publisher

MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070428021010024

Keywords

pyrrolooxazinetrione; enamino ketone; 5,5-dimethylcyclohex-2-en-1-one; spiro[indole-3,2 '-pyrrole]trione; X-ray analysis

Funding

  1. Russian Foundation for Basic Research [19-33-90222]
  2. Government of Perm Krai
  3. Ministry of Science and Higher Education of the Russian Federation [FSNF-2020-0008]

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In this study, 8-Aroyl-3,4-dihydropyrrolo[2,1-c][1,4]oxazine-1,6,7(1H)-triones reacted with 3-(arylamino)-5,5-dimethylcyclohex-2-en-1-ones to yield 3'-aroyl-1-aryl-4'-hydroxy-1'-(2-hydroxyalkyl)-6,6-dimethyl-6,7-dihydrospiro[indole-3,2'-pyrrole]-2,4,5'(1H,1'H,5H)-triones, and the product structure was confirmed by X-ray analysis.
8-Aroyl-3,4-dihydropyrrolo[2,1-c][1,4]oxazine-1,6,7(1H)-triones reacted with 3-(arylamino)-5,5-dimethylcyclohex-2-en-1-ones to give 3 '-aroyl-1-aryl-4 '-hydroxy-1 '-(2-hydroxyalkyl)-6,6-dimethyl-6,7-dihydrospiro[indole-3,2 '-pyrrole]-2,4,5 '(1H,1 ' H,5H)-triones. The product structure was confirmed by X-ray analysis.

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