Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 4, Pages 721-726Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01147a
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Funding
- National Natural Science Foundation of China [21901220]
- Young Scholars Research Fund of Yantai University [HY19B06]
- Key Laboratory of Chemical Engineering and Process of Shandong Province
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A novel catalytic asymmetric tandem reaction of tertiary enamides was developed using a chiral Diph-Pybox/Cu(OTf)(2) complex. The method allows for the expedited synthesis of indolizino[8,7-b]indole derivatives with high yields and excellent enantioselectivity and diastereoselectivity.
An exquisite catalytic asymmetric tandem reaction of tertiary enamides catalyzed by a chiral Diph-Pybox/Cu(OTf)(2) complex was developed. The method, which comprised an enantioselective intramolecular addition of tertiary enamides to ketonic carbonyls followed by the diastereoselective interception of acyliminium by a tethered indole moiety, enables the expeditious synthesis of indolizino[8,7-b]indole derivatives with high yields, and excellent enantioselectivity and diastereoselectivity.
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