Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 6, Issue 1, Pages 12-21Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.10.006
Keywords
cardiac fibrosis; galectin-3; heart failure
Categories
Funding
- National Institutes of Health [NIH-5T32HL094301-07, R01-HL134893, R01-HL140224, K24-HL153669]
- Gilead Sciences Research Scholar Award
- Gilead Sciences
- Bayer
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In this trial, higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, but treatment with modified citrus pectin did not change collagen markers. Further investigation is needed for the effect of Gal-3 inhibition among individuals with heart failure.
We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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