Journal
DALTON TRANSACTIONS
Volume 50, Issue 6, Pages 2177-2182Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0dt03958f
Keywords
-
Categories
Funding
- Department of Science and Technology (DST) and National Research Foundation (NRF) of South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [62062]
- ISRR grant from the NRF of South Africa [119259]
Ask authors/readers for more resources
A new Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been synthesized and characterized, showing high Phi(Delta) value and promising photodynamic activity against MCF-7 breast cancer cells. These results suggest that Sn(IV) tetraarylchlorins like SnC are suitable candidates for further photodynamic therapy studies.
A new readily-synthesized Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been prepared and fully characterized by various spectroscopic techniques and its photophysical and photochemical properties, such as the singlet oxygen quantum yield (Phi(Delta)), fluorescence quantum yield (Phi(F)), triplet lifetime (tau(T)) and photostability, have been evaluated. SnC has an unusually high Phi(Delta) value of 0.89 in DMF. Studies on the photodynamic activity against MCF-7 breast cancer cells exhibited a very low IC50 value of 0.9 mu M and high phototoxicity (dark versus light) indices of >27.8 after irradiation with a 660 nm Thorlabs LED (280 mW cm(-2)). The results demonstrate that Sn(IV) tetraarylchlorins of this type are suitable candidates for further in-depth PDT studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
