Journal
AGING-US
Volume 13, Issue 3, Pages 3342-3352Publisher
IMPACT JOURNALS LLC
Keywords
esophageal cancer; drug-resistance; hypermethylation; MCTP1
Categories
Funding
- Fundamental Research Funds for the Central Universities [WK9110000090]
- Youth Technical Backbone Fund of West Branch of the First Affiliated Hospital of USTC [2018YJQN005]
- Youth Fund of Anhui Cancer Hospital
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Studies have shown that drug-resistance is a major obstacle in the effective treatment of cancers, and the hypermethylation of the MCTP1 gene in drug-resistant esophageal cancer cells leads to its down-regulation, influencing cell migration and apoptosis. This suggests MCTP1 activates drug-resistance in esophageal cancer cells, indicating potential implications for the design of new biomarkers for esophageal cancer treatment.
Accumulating studies have demonstrated that drug-resistance remains a great obstacle for the effective treatment of cancers. Esophageal cancer is still one of the most common cancers worldwide, which also suffers from the drug-resistance during clinical treatment. Here we performed drug-resistance profiling assays and identified several drug-resistant and drug-sensitive esophageal cancer cell lines. The following methylation sequencing showed that the MCTP1 gene is hypermethylated in the drug-resistant esophageal cancer cells. As a result, the expression of MCTP1 is down-regulated in the drug-resistant esophageal cancer cells. Down-regulation of MCTP1 also affects the migration and apoptosis of esophageal cancer cells, as revealed by the wound-healing and apoptosis assays. Further investigations proposed two signaling pathways that might involve in the MCTP1-mediated drug-resistance of esophageal cancer cells. All these results suggested that MCTP1 activates the drug-resistance of esophageal cancer cells, which has implications for further design of new biomarker of esophageal cancer treatment.
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