Journal
SOFT MATTER
Volume 17, Issue 7, Pages 1842-1849Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sm00836b
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Funding
- Gordon and Betty Moore Foundation [GBMF5263.02]
- Cottrell College Science Award from the Research Corporation
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In the morphogenesis of tissues and tumors, cells with different mechanical properties interact with neighbors, leading to phase separation into clusters with distinct morphologies and transport properties for the different cell types. The results deviate from behavior characteristic of phase separation in binary fluids and provide mechanistic insights into intercellular phase separation during development and disease.
During the morphogenesis of tissues and tumors, cells often interact with neighbors with different mechanical properties, but the understanding of its role is lacking. We use active Brownian dynamics simulations to study a model co-culture consisting of two types of cells with the same size and self-propulsion speed, but different mechanical stiffness and cell-cell adhesion. As time evolves, the system phase separates out into clusters with distinct morphologies and transport properties for the two cell types. The density structure factors and the growth of cell clusters deviate from behavior characteristic of the phase separation in binary fluids. Our results capture emergent structure and motility previously observed in co-culture experiments and provide mechanistic insights into intercellular phase separation during development and disease.
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