Potent E. coil M-17 Growth Inhibition by Ultrasonically Complexed Acetylsalicylic Acid-ZnO-Graphene Oxide Nanoparticles

A single-step ultrasonic method (20 kHz) is demonstrated for the complexation of acetylsalicylic acid (ASA)-ZnO-graphene oxide (GO) nanoparticles with an average size of <70 nm in aqueous solution. ASA-ZnO-GO more efficiently inhibits the growth of probiotic Escherichia coli strain M-17 and exhibits enhanced antioxidant properties than free ASA and ASA-ZnO in neutralization of hydroxyl radicals in the electro-Fenton process. This improved function of ASA in the ASA- ZnO-GO can be attributed to the well-defined cone-shaped morphology, the surface structure containing hydroxyl and carboxylate groups of ZnO-GO nanoparticles, which facilitated the complexation with ASA.

Automated summary

The study demonstrated a single-step ultrasonic method to prepare ASA-ZnO-GO nanoparticles in aqueous solution with an average size of <70 nm. The ASA-ZnO-GO showed more efficient inhibition of E. coli growth and enhanced antioxidant properties compared to free ASA and ASA-ZnO in neutralizing hydroxyl radicals. The improved function of ASA in ASA-ZnO-GO can be attributed to the well-defined morphology and surface characteristics of ZnO-GO nanoparticles, which facilitated the complexation with ASA.