Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 15, Pages 3370-3373Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00347j
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Funding
- NSFC [81473100, 31900033]
- DIMP [2018ZX09711-001-001-017]
- Primary Research AMP
- Development Plan of Shanxi Province [201903D321110]
- Hospital Level Research Fund of Heping Hospital [HPYJ201927]
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The study achieved highly efficient asymmetric Michael-type Friedel-Crafts alkylation of naphthol and unsaturated pyrazolones under mild reaction conditions. A wide range of substrates were tolerated with excellent yields (up to 99%) and reasonable enantioselectivities (up to 96% ee) in the presence of the chiral squaramide catalyst.
The first method for highly efficient asymmetric Michael-type Friedel-Crafts alkylation of naphthol and unsaturated pyrazolones has been accomplished under mild reaction conditions. In the presence of the chiral squaramide catalyst, a wide range of substrates are tolerated in excellent yields (up to 99%) with reasonable enantioselectivities (up to 96% ee).
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