Niobium pentoxide, a recyclable heterogeneous solid surface catalyst for the synthesis of α-amino phosphonates

Niobium pentoxide, a bifunctional solid surface catalyst, has been successfully employed to facilitate the three-component reaction between aldehydes, amines and triethyl phosphite at room temperature under solvent-free conditions to generate alpha -amino phosphonate in moderate to good yields. The catalyst can be recycled through simple filtration and reused to effect this transformation. Graphic abstract

Automated summary

Niobium pentoxide is an efficient catalyst that can facilitate the three-component reaction between aldehydes, amines, and triethyl phosphite to generate alpha-amino phosphonate under solvent-free conditions at room temperature. The catalyst is recyclable through simple filtration for repeated use in this transformation.