NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, the treatment effect of adult B-cell ALL is less effective and remains a big challenge. In order to explore the pathogenesis of adult B-cell ALL and find new diagnostic biomarkers to develop sensitive diagnostic tools, we investigated the plasma metabolites of adult B-cell ALL by using H-1 NMR (nuclear magnetic resonance) metabolomics. Relative to healthy controls, adult B-cell ALL patients showed abnormal metabolism, including glycolysis, gluconeogenesis, amino acid metabolism, fatty acid metabolism and choline phospholipid metabolism. What's more important, we also found that the optimal combination of choline, tyrosine and unsaturated lipids has the potential to diagnose and prognose adult B-cell ALL in the clinic.

Automated summary

Treatment of adult B-cell acute lymphoblastic leukemia (ALL) remains a challenge, with less effective outcomes compared to childhood ALL. Metabolomic analysis using H-1 NMR revealed abnormal metabolism in adult B-cell ALL patients, highlighting the potential diagnostic value of choline, tyrosine, and unsaturated lipids.