Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 46, Issue -, Pages 15-31Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2017.05.001
Keywords
Glucocorticoid receptor; Nuclear factor kappa-light-chain-enhancer of activated B cells; Stress; Depression; Anxiety; PTSD; FKBP5; Inflammation; Glucocorticoid resistance
Categories
Funding
- NIH [NR014886, MH110364, T32-GM008602]
Ask authors/readers for more resources
Mutual regulation and balance between the endocrine and immune systems facilitate an organism's stress response and are impaired following chronic stress or prolonged immune activation. Concurrent alterations in stress physiology and immunity are increasingly recognized as contributing factors to several stress-linked neuropsychiatric disorders including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF kappa B) - effectors of the stress and immune axes, respectively - may play a key role in mediating the harmful effects of chronic stress on mood and behavior. Here, we first review the molecular mechanisms of GR and NF kappa B interactions in health, then describe potential shifts in the GR-NF kappa B dynamics in chronic stress conditions within the context of brain circuitry relevant to neuropsychiatric diseases. Furthermore, we discuss developmental influences and sex differences in the regulation of these two transcription factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available