Journal
RSC MEDICINAL CHEMISTRY
Volume 12, Issue 2, Pages 288-292Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0md00284d
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Funding
- University of East Anglia, PDT Norfolk & the Anthony Long Trust
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The study utilized functionalized gold nanoparticles to target cancer cells overexpressing epidermal growth factor receptor, achieving selective phototoxicity through the photosensitizer with minimal impact on normal cells.
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-beta AAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
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