Liver organoids in domestic animals: an expected promise for metabolic studies

The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol, drugs, antibiotics, etc.). The development of a relevant model that reproduces some of the functions of this tissue has become a challenge, in particular for human medicine. Thus, in recent years, most studies aimed at producing hepatocytes in vitro with the goal of developing hepatic 3D structures have been carried out in the human model. However, the tools and protocols developed using this unique model can also be considered to address physiological questions specific to this tissue in other species, such as the pig, chicken, and duck. Different strategies are presently being considered to carry out in vitro studies of the hepatic metabolism of these agronomic species.

Automated summary

Developing a model that replicates the functions of the liver has become a challenge for human medicine, with most studies focusing on producing hepatocytes in vitro for the development of hepatic 3D structures. However, tools and protocols developed in human models can also be applied to studying the physiological questions specific to liver tissue in other species such as pigs, chickens, and ducks. Presently, different strategies are being considered for conducting in vitro studies on hepatic metabolism in these agronomic species.