Journal
FRONTIERS IN HUMAN NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2017.00442
Keywords
depression; quantitative susceptibility mapping; iron; putamen; thalamus
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Funding
- National Natural Science Foundation of China [81301194, 81525014]
- Jiangsu Provincial Key Research and Development Plan [BE2017698]
- project of Jiangsu Provincial Health and Family Planning Commission [Q201605]
- project of Young Key Teacher Training [5524040001]
- National Postdoctoral Foundation of China [2016M601702]
- project of Jiangsu Provincial Young Medical Talents [QNRC2016832, QNRC2016460]
- Postdoctoral Foundation of Jiangsu Province [1601134B]
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Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in depressed patients and evaluated whether it is related to severity. We included three groups of age- and gender-matched participants: 30 patients with mild-moderate depression (MD), 14 patients with major depression disorder (MDD) and 20 control subjects. All participants underwent MR scans with a 3D gradient-echo sequence reconstructing for QSM and performed the 17-item Hamilton Depression Rating Scale (HDRS) test. In MDD, the susceptibility value in the bilateral putamen was significantly increased compared with MD or control subjects. In addition, a significant difference was also observed in the left thalamus in MDD patients compared with controls. However, the susceptibility values did not differ between MD patients and controls. The susceptibility values positively correlated with the severity of depression as indicated by the HDRS scores. Our results provide evidence that brain iron deposition may be associated with depression and may even be a biomarker for investigating the pathophysiological mechanism of depression.
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