De novo approach for the synthesis of water-soluble and non-interlocked organic cagesinterlocked

Research on self-assembled metallosupramolecular architectures has bloomed in recent times. Analogous metal-free organic architectures with water solubility are highly challenging. We report here a unique class of triazine based immidazolium water-soluble metal-free interlocked organic cage (1), which was synthesized in a one-pot reaction without using dynamic covalent chemistry and without any chromatographic separation. An analogous non-interlocked cage (2) was also successfully achieved by steric control using different positional isomers of the building blocks.

Automated summary

Research on self-assembled metallosupramolecular architectures has seen a recent surge. A unique class of triazine based immidazolium water-soluble metal-free interlocked organic cage was successfully synthesized without the use of dynamic covalent chemistry or chromatographic separation. An analogous non-interlocked cage was also achieved by steric control using different positional isomers of the building blocks.