Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 32, Pages 3877-3880Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00765c
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Funding
- Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) from AMED) [JP20am0101099]
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In this study, a new class of difluoromethylated diarylmethanes was synthesized through Fe(OTf)(3)-catalyzed reaction, demonstrating the relationship between substrate structure and catalyst behavior.
The Fe(OTf)(3)-catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf)(3) behaves as the Lewis acid, and that the phosphate leaving group and o- or p-alkoxy substituents on the substrates are necessary for the Fe(OTf)(3)-catalyzed reaction to proceed under mild conditions.
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