Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 33, Pages 4031-4034Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00932j
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [EXC-2033, 390677874]
- Research Training Group Confinement controlled chemistry'' [GRK 2341, 331085229]
- DFG's Heisenberg programme [ME 4267/5-1, 418661145]
- Boehringer Ingelheim Foundation (BIS)
- Coordenacao de Aperfeicoamento de Pessoal de Ni'vel Superior (CAPES)
- Alexander von Humboldt foundation
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In this study, the IR and VCD spectra of azithromycin were reported, with computational analysis revealing the importance of a single water molecule in stabilizing the hydrogen bonding network and determining the VCD spectral signatures. The presence of this water molecule was essential for understanding the conformational dynamics of azithromycin.
We report the IR and VCD spectra of azithromycin, a macrolide antibiotic with a total of 18 stereogenic centers. The computational analysis of the spectra reveals that a single water molecule has to be considered in the conformational search. Its key role is the stabilization of an extended hydrogen bonding network and an otherwise unstable conformation that determines the VCD spectral signatures.
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