Journal
THERANOSTICS
Volume 11, Issue 9, Pages 4090-4102Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.53101
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Funding
- U.S. Department of Energy Office of Science [DE-SC0019393]
- National Institute of Health [1R01EB0280 78-01A1]
- European Commission [667933-2]
- German Federal Ministry of Education and Research (BMBF) within the Forschungsfabrik Mikroelektronik Deutschland [16FMD02]
- U.S. Department of Energy (DOE) [DE-SC0019393] Funding Source: U.S. Department of Energy (DOE)
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In this study, SERS nanoprobes combined with SERDS detection were used to accurately detect tumors in a xenograft murine model, demonstrating improved sensitivity and accuracy. This method has the potential to enhance the clinical translation of Raman/SERS biomedical applications.
removing the entire tumor without harming surrounding tissue is critical; however, due to the lack of intraoperative imaging techniques, surgeons rely on visual and physical inspection to identify tumors. Surface-enhanced Raman scattering (SERS) is emerging as a non-invasive optical alternative for intraoperative tumor identification, with high accuracy and stability. However, Raman detection requires dark rooms to work, which is not consistent with surgical settings. Methods: Herein, we used SERS nanoprobes combined with shifted-excitation Raman difference spectroscopy (SERDS) detection, to accurately detect tumors in xenograft murine model. Results: We demonstrate for the first time the use of SERDS for in vivo tumor detection in a murine model under ambient light conditions. We compare traditional Raman detection with SERDS, showing that our method can improve sensitivity and accuracy for this task. Conclusion: Our results show that this method can be used to improve the accuracy and robustness of in vivo Raman/SERS biomedical application, aiding the process of clinical translation of these technologies.
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