A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.

Automated summary

The study proposed a two-pronged concept combining photodynamic therapy and epithelial-mesenchymal transition blockade to combat basal-like breast cancer metastasis. Ce6/Epa nanoparticles effectively prevented BLBC metastasis in vivo, offering a promising dual strategy against BLBC metastasis.