Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 18, Pages 2305-2308Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc08162k
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Funding
- National Natural Science Foundation of China (NSFC) [82061148009, 21872083]
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The study proposed a two-pronged concept combining photodynamic therapy and epithelial-mesenchymal transition blockade to combat basal-like breast cancer metastasis. Ce6/Epa nanoparticles effectively prevented BLBC metastasis in vivo, offering a promising dual strategy against BLBC metastasis.
A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.
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