4.5 Review

Natural bio-based monomers for biomedical applications: a review

Journal

BIOMATERIALS RESEARCH
Volume 25, Issue 1, Pages -

Publisher

SPRINGERNATURE
DOI: 10.1186/s40824-021-00208-8

Keywords

Natural bio-based monomers; Itaconic acid; Succinic acid; Citric acid; Hyaluronic acid; Glutamic acid

Funding

  1. Chung-Ang University
  2. Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Republic of Korea [HI15C1744]

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Synthetic and semi-synthetic polymer materials are widely used in biomedical applications, while natural bio-based monomeric materials present a novel avenue for developing biocompatible, biodegradable, and non-toxic products. Researchers are focused on creating new products with increased eco-friendliness, biocompatibility, and intrinsic biological activity for the well-being of humanity.
In recent years, synthetic and semi-synthetic polymer materials have been widely used in various applications. Especially concerning biomedical applications, their biocompatibility, biodegradability, and non-toxicity have increased the interest of researchers to discover and develop new products for the well-being of humanity. Among the synthetic and semi-synthetic materials, the use of natural bio-based monomeric materials presents a possible novel avenue for the development of new biocompatible, biodegradable, and non-toxic products. The purpose of this article is to review the information on the role of natural bio-based monomers in biomedical applications. Increased eco-friendliness, biocompatibility, biodegradability, non-toxicity, and intrinsic biological activity are some of the attributes which make itaconic, succinic, citric, hyaluronic, and glutamic acids suitable potential materials for biomedical applications. Herein, we summarize the most recent advances in the field over the past ten years and specifically highlight new and interesting discoveries in biomedical applications.

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