4.7 Article

Analysis of Asymptomatic and Presymptomatic Transmission in SARS-CoV-2 Outbreak, Germany, 2020

Journal

EMERGING INFECTIOUS DISEASES
Volume 27, Issue 4, Pages 1159-1163

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2704.204576

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Funding

  1. European Public Health Microbiology Training at the European Centre for Disease Prevention and Control (ECDC) Fellowship Programme

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The study found that asymptomatic case-patients did not transmit the virus, while the highest transmission rate was through presymptomatic exposure. Rapid quarantine of close contacts, whether symptomatic or asymptomatic, is essential to prevent presymptomatic transmission.
We determined secondary attack rates (SAR) among close contacts of 59 asymptomatic and symptomatic coronavirus disease case-patients by presymptomatic and symptomatic exposure. We observed no transmission from asymptomatic case-patients and highest SAR through presymptomatic exposure. Rapid quarantine of close contacts with or without symptoms is needed to prevent presymptomatic transmission.

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