Journal
ONCOIMMUNOLOGY
Volume 10, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2021.1893466
Keywords
Regulated cell death; immunogenic cell death; cancer immunosurveillance; oncogene; tumor suppressor
Categories
Funding
- University of Guelph Startup
- OICR
- Wolf Lebovic Cancer Genomics and Immunity Program
- Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR)-Projets blancs
- ANR
- ERA-Net for Research on Rare Diseases [AMMICa US23/CNRS UMS3655]
- Association pour la recherche sur le cancer (ARC)
- Association Ruban Rose
- Canceropole Ile-deFrance
- Fondation pour la Recherche Medicale (FRM)
- European Research Area Network on Cardiovascular Diseases
- Gustave Roussy Odyssea
- European Union
- Fondation Carrefour
- Highend Foreign Expert Program in China [GDW20171100085]
- Institut National du Cancer (INCa)
- Inserm (HTE)
- Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology [ANR-18-IDEX-0001]
- RHU Torino Lumiere
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
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The immune system recognizes tumor cells and initiates a specific T cell response, but tumors have developed mechanisms to evade immune surveillance by suppressing immunogenic cell death.
The immune system can recognize tumor cells to mount antigen-specific T cell response. Central to the establishment of T cell-mediated adaptive immunity are the inflammatory events that facilitate antigen presentation by stimulating the expression of MHC and costimulatory molecules and the secretion of pro-inflammatory cytokines. Such inflammatory events can be triggered upon cytotoxic treatments that induce immunogenic cancer cell death modalities. However, cancers have acquired a plethora of mechanisms to subvert, or to hide from, host-encoded immunosurveillance. Here, we discuss how tumor intrinsic oncogenic factors subvert desirable intratumoral inflammation by suppressing immunogenic cell death.
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