Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 109, Issue -, Pages 167-188Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2016.12.004
Keywords
Redox probes; HyPer; RoGFP; NAD; NADH; NADPH; Imaging; D-aminoacid oxidase
Funding
- Russian Foundation for Basic Research [16-34-60175, 15-34-20805, 15-54-74003]
- Molecular and Cell Biology Program of the Russian Academy of Sciences
- [MK-6339.2016.4]
Ask authors/readers for more resources
Redox reactions play a key role in maintaining essential biological processes. Deviations in redox pathways result in the development of various pathologies at cellular and organismal levels. Until recently, studies on transformations in the intracellular redox state have been significantly hampered in living systems. The genetically encoded indicators, based on fluorescent proteins, have provided new opportunities in biomedical research. The existing indicators already enable monitoring of cellular redox parameters in different processes including embryogenesis, aging, inflammation, tissue regeneration, and pathogenesis of various diseases. In this review, we summarize information about all genetically encoded redox indicators developed to date. We provide the description of each indicator and discuss its advantages and limitations, as well as points that need to be considered when choosing an indicator for a particular experiment. One chapter is devoted to the important discoveries that have been made by using genetically encoded redox indicators.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available