Journal
JOURNAL OF ORTHOPAEDICS
Volume 23, Issue -, Pages 216-218Publisher
ELSEVIER
DOI: 10.1016/j.jor.2021.01.009
Keywords
Denosumab administration; Spinal metastasis; TRAP-5b; BAP
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Denosumab treatment resulted in significantly lower TRAP-5b values in both osteosclerotic and osteolytic lesion groups at 6 months, indicating its effectiveness in patients with spinal metastasis.
Background: We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. Methods: Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. Results: At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. Conclusions: This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.
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