Journal
RSC ADVANCES
Volume 11, Issue 19, Pages 11083-11165Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra00392e
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This review summarizes the research progress made in utilizing alpha-aminoazaheterocycles as synthetic precursors in multicomponent reactions over the past decade, emphasizing the importance and feasibility of multicomponent reactions as a synthetic method.
Aromatic alpha-aminoazaheterocycles are the focus of significant investigations and exploration by researchers owing to their key role in diverse biological and physiological processes. The existence of their derivatives in numerous drugs and alkaloids is due to their heterocyclic nitrogenous nature. Therefore, the synthesis of a structurally diverse range of their derivatives through simple and convenient methods represents a vital field of synthetic organic chemistry. Multicomponent reactions (MCRs) provide a platform to introduce desirable structure diversity and complexity into a molecule in a single operation with a significant reduction in the use of harmful organic waste, and hence have attracted particular attention as an excellent tool to access these derivatives. This review covers the advances made from 2010 to the beginning of 2020 in terms of the utilization of alpha-aminoazaheterocycles as synthetic precursors in MCRs.
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