4.6 Article

A novel one-pot synthesis of flavones

Journal

RSC ADVANCES
Volume 11, Issue 19, Pages 11655-11662

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra00534k

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Funding

  1. Ministry of Science and Technology of the Republic of China (Taiwan) [MOST 109-2113-M-037-014-MY3]

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The paper presents a one-pot facile route for the synthesis of functionalized flavones mediated by BiCl3/RuCl3, involving intermolecular ortho-acylation of substituted phenols with cinnamoyl chlorides, and intramolecular cyclodehydrogenation of the resulting o-hydroxychalcones. The reaction conditions are discussed.
In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecular ortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resulting o-hydroxychalcones. The reaction conditions are discussed herein.

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