Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 22, Pages 2812-2815Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00292a
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- NNSFC [21861132001, 21971127, 21772099]
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The hyaluronidase-responsive polysaccharide supramolecular assembly with specific cancer cell targeting and controlled drug release abilities shows potential in enhancing the efficacy of chemotherapy by inhibiting ATP hydrolysis.
A hyaluronidase-responsive polysaccharide supramolecular assembly was constructed from an amphiphilic beta-cyclodextrin bearing seven hexylimidazolium units (AMCD), adamantyl-grafted hyaluronic acid, and chlorambucil, which showed specific cancer cell targeting and controlled drug release abilities. Interestingly, ternary supramolecular assembly can disassemble in the presence of hyaluronidase, and the released AMCD can assemble with ATP to form a stable 1 : 1 complex, which enhanced the efficacy of chlorambucil on cancer chemotherapy by inhibiting ATP hydrolysis.
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