Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 11, Pages 2504-2509Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00141h
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- Ministere de l'Enseignement Superieur, de la Recherche et de l'Innovation (MESRI)
- Centre National de la Recherche Scientifique (CNRS)
- China Scholarship Council (CSC)
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The kinetic resolution of 2-aryl tetrahydro-4-quinolone derivatives was efficiently achieved through rhodium-catalysed asymmetric transfer hydrogenation using HCO2H/DABCO as the hydrogen source, providing enantiomerically enriched products with high enantioselectivity and selectivity factors.
The kinetic resolution of 2-aryl tetrahydro-4-quinolone derivatives was efficiently achieved by rhodium-catalysed asymmetric transfer hydrogenation using HCO2H/DABCO as the hydrogen source. The reaction afforded the enantiomerically enriched 2-aryl-2,3-dihydroquinolin-4(1H)-ones with excellent levels of enantioselectivity (up to >99% ee) as well as the corresponding synthetically useful enantiomerically enriched 2-aryl tetrahydro-4-quinolols in high isolated yields and up to >99% enantioselectivity with high selectivity factors (s up to 1057).
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