Journal
AGEING RESEARCH REVIEWS
Volume 21, Issue -, Pages 78-94Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2015.04.001
Keywords
Frailty; Ageing; Phenotype; Survey of Health, Ageing, and Retirement in Europe; Systematic review; Secondary analysis
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP209888]
- Fountain Family Innovation Fund of the Queen Elizabeth II Health Care Foundation, Halifax, Nova Scotia Canada
- CIHR
- European Commission through the 5th Framework Programme [QLK6-CT-2001-00360]
- European Commission through the 6th Framework Programme (SHARE-I3) [RII-CT-2006-062193]
- European Commission through the 7th Framework Programme (SHARE-PREP) [211909]
- European Commission through the 7th Framework Programme (SHARE-LEAP) [227822]
- European Commission through the 7th Framework Programme (SHARE M4) [261982]
- U.S. National Institute on Aging [U01 AG09740-13S2, P01 AG005842, P01 AG08291, P30 AG12815, R21 AG025169, Y1-AG-4553-01, IAG BSR06-11, OGHA 04-064]
- German Ministry of Education and Research
- European Commission through the 6th Framework Programme (COMPARE) [CIT5-CT-2005-028857]
- European Commission through the 6th Framework Programme (SHARELIFE) [CIT4-CT-2006-028812]
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We conducted a systematic review to determine variability in how the criteria of the frailty phenotype (grip strength, weight loss, exhaustion, walking speed, physical activity) were assessed. We then evaluated the impact on estimating prevalence and mortality of modifying the criteria, using the Survey of Health, Ageing, & Retirement in Europe (SHARE). Five databases were searched for original research articles published after 2000, which evaluated frailty using the phenotypic criteria. Among the 264 included studies, 24 studies provided enough information to demonstrate that all criteria were assessed as proposed in the original frailty phenotype study by Fried et al. (2001). Physical inactivity and weight loss were the criteria most often modified. We then created 262 phenotypes from SHARE based on common modifications found in the review. Among these phenotypes, frailty prevalence ranged from 12.7% to 28.2%. Agreement with the primary frailty phenotype ranged from 0.662 to 0.967 and internal consistency ranged from 0.430 to 0.649. Women had 2.1-16.3% higher frailty prevalence than men. Areas under receiver operating characteristic curves for discriminating five-year mortality ranged from 0.607 (95% CI: 0.583-0.630) to 0.668 (0.645-0.691). The frailty phenotype often has been modified, and these modifications have important impact on its classification and predictive ability. (C) 2015 Elsevier B.V. All rights reserved.
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