Journal
CHEMICAL SCIENCE
Volume 12, Issue 10, Pages 3393-3405Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc03096a
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Funding
- Beckman Institute Graduate Fellowship
- Alfred P. Sloan Foundation
- National Science Foundation [CHE 1752879]
- National Institutes of Health [R35GM133581]
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In vivo imaging is a powerful tool for studying biological processes and guiding the development of diagnostics and therapies for diseases. Recent advancements in in vivo ABS applications are focusing on activity-based sensing and near-infrared imaging modalities.
In vivo imaging is a powerful approach to study biological processes. Beyond cellular methods, in vivo studies allow for biological stimuli (small molecules or proteins) to be studied in their native environment. This has the potential to aid in the discovery of new biology and guide the development of diagnostics and therapies for diseases. To ensure selectivity and an observable readout, the probe development field is shifting towards activity-based sensing (ABS) approaches and near-infrared (NIR) imaging modalities. This perspective will highlight recent in vivo ABS applications that utilize NIR imaging platforms.
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