Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

Exploiting new non-metal-based peroxidase-mimic nanoenzymes for chemodynamic therapy (CDT) in cancer treatment is an active and challenging field. Here, we found that activated carbon nanoparticles (denoted as ANs) fabricated from coconut shell have satisfactory peroxidase-mimic nanoenzyme activity. Based on this positive result, gadodiamide, a clinically used nuclear magnetic imaging contrast agent, was loaded inside the AN pores and encapsulated by polyvinylpyrrolidone (PVP) to obtain Gd@PANs. PANs (ANs modified using PVP) efficiently catalyze the massive decomposition of endogenous hydrogen peroxide (H2O2) inside cancer cells to produce toxic oxidized hydroxyl radicals (OH) for the CDT treatment of cancer, but they showed no toxicity toward normal cells. Additionally, under 808 nm laser irradiation, the photothermal conversion efficiency of the PANs reaches 45.20%, ensuring their effective photothermal therapy (PTT) treatment functionality. Simultaneously, during PTT treatment, the heating effect significantly enhances the peroxidase-mimic activity of the PANs to achieve an ideal PTT-CDT synergistic therapeutic outcome. Gd@PANs can also be used for the T1-magnetic resonance imaging (MRI) of tumors to integrate treatment and diagnosis.

Automated summary

The study utilizes activated carbon nanoparticles (ANs) derived from coconut shell to exhibit peroxidase-mimic nanoenzyme activity for chemodynamic therapy (CDT) in cancer treatment. The PANs also show efficient photothermal conversion efficiency for photothermal therapy (PTT), with heating effect enhancing peroxidase-mimic activity, achieving a synergistic PTT-CDT therapeutic outcome. Additionally, Gd@PANs can be used for T1-magnetic resonance imaging (MRI) of tumors, integrating treatment and diagnosis.