Preparation and characterization of poly (E-CAPROLACTONE) nano fibers by electrospinning technique for tissue enginerring applications

Electro spinning is a technique of producing nanofibers from polymer solution under the influence of electrostatic forces. In this work, we investigated the formation of nanofibers by electro spinning technique using synthetic biodegradable poly (epsilon-caprolactone) (PCL) polymer sample. It provides a relatively inexpensive method of creating a variety of nanofibers. Nano to micro structure recyclable Poly (epsilon-caprolcatone) materials were prepared by electro-spinning of solutions PCL in the range of 10-15 % (W/V) at constant voltage of 18Kv. Electrospun fabrics Hus obtained using chloroform as a solvent. The impacts of different parameters, including stream rate, and solution parameters, for example, focus and dissolvable were likewise inspected. While expanding arrangement focus, the morphology changed from beaded filaments to the uniform fibers. The compatibility of the PCL nanofibers with physiological fluids was assessed through standard assay procedures using simulated body fluids. The morphology of the fibers was investigated by scanning electron microscopy, nanofibers crystallinity and function groups were examined by X-ray diffraction analysis and Fourier transformer infrared spectroscopy. From this study, it could suggest that the formation of nanofibers were obtained in the range of 100 nm-350 nm thickness. The obtained result concluded that the PCL nanofibers could be suitable for tissue engineering applications. (C) 2020 Elsevier Ltd. All rights reserved.

Automated summary

In this study, electrospun PCL nanofibers were successfully prepared and their morphology, crystallinity, functional groups, and compatibility with physiological fluids were investigated. The results suggest that PCL nanofibers could be suitable for tissue engineering applications.