Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 113, Issue 2, Pages 437-445Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/nqaa288
Keywords
muscle strength; physical function; aging; nutrition; diet; epidemiology; community-based; sarcopenia; prospective cohort study; food frequency questionnaire
Categories
Funding
- National Institute on Aging [R01 AG051728, R01 AR53205, R01 AR/AG41398, U01 HL130114]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01 AG051728, R01 AR53205, R01 AR/AG41398, U01 HL130114]
- National Heart, Lung, and Blood Institute's Framingham Heart Study [HHSN268201500001I]
- American Society for Bone and Mineral Research Grants in Aid Program Award
- National Institute on Aging's of the Boston Claude D. Pepper Center Older American Independence Centers (OAIC) [1P30AG031679]
- Peter and Barbara Sidel Fund
- USDA [58-1950-4-003]
- National Institute on Aging's support of the Boston Claude D. Pepper Center OAIC [1P30AG031679]
- Cardiovascular Health Study Research Resources for the Cardiovascular Health of Adults [P30 AG024827]
- Pittsburgh Older Americans Independence Center
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Higher antioxidant intake was associated with an increase in grip strength and faster gait speed, highlighting the importance of dietary antioxidants in maintaining muscle strength and physical function.
Background: Lower antioxidant serum concentrations have been linked to declines in lean mass and physical function in older adults. Yet population data on the effect of dietary antioxidants on loss of muscle strength and physical function are lacking. Objective: We sought to determine the association of antioxidant intake [vitamin C. vitamin E. and total and individual carotenoids (acarotene, beta-carotene, beta-cryptoxanthin. lycopene, and lutein + zeaxanthin)] with annualized change in grip strength and gait speed in adults from the Framingham Offspring study. Methods: This prospective cohort study included participants with a valid FFQ at the index examination and up to 2 prior examinations and at >= 2 measures of primary outcomes: grip strength (n = 2452) and/or gait speed (n = 2422) measured over 3 subsequent examinations. Annualized change in grip strength (kg/y) and change in gait speed (m/s/y) over the follow-up period were used. Linear regression was used to calculate( )beta coefficients and P values, adjusting for covariates. Results: Mean +/- SD age of participants was 61 +/- 9 y (range: 3388 y). Median intakes (IQR, mg/d) of vitamin C, vitamin E, and total carotenoid across available examinations were 209.2 (133.1394.2), 27.1 (7.4-199.0), and 15.3 (10.4-21.3). respectively. The mean follow-up time was similar to 12 +/- 2 y (range: 4.5-15.4 y). In the sex-combined sample. higher intakes of total carotenoids, lycopene, and lutein + zeaxanthin were associated with increased annualized change in grip strength [beta (SE) per 10-mg higher intake/d, range: 0.0316 (0.0146) to 0.1223 (0.0603) kg/y)]. All antioxidants except for vitamin C were associated with faster gait speed [beta (SE) per 10-mg higher intake/d, range: 0.00008 (0.00004) to 0.0187 (0.0081) m/s/y]. Conclusions: Higher antioxidant intake was associated with increase in grip strength and faster gait speed in this cohort of adults. This finding highlights the need for a randomized controlled trial of dietary antioxidants and their effect on muscle strength and physical function.
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