Isolable small-molecule cysteine sulfenic acid

An isolable small-molecule cysteine sulfenic acid (Cys-SOH) protected by a molecular cradle was synthesized by direct oxidation of the corresponding cysteine thiol and its structure was established by X-ray crystallographic analysis. Studies on biologically relevant reactivity indicated its usefulness as a biorepresentative small-molecule sulfenic acid model.

Automated summary

In this study, an isolable small-molecule cysteine sulfenic acid protected by a molecular cradle was successfully synthesized through direct oxidation of the corresponding cysteine thiol, and its structure was determined by X-ray crystallographic analysis. Biological studies showed its potential as a useful model for studying biorelevant reactivity.