Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 20, Pages 2527-2530Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc08146a
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Funding
- Singapore National Research Foundation Investigatorship [NRF-NRFI2017-09]
- Ministry of Education Academic Research Fund Tier 2 [MOE2015-T2-1-092]
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A recent study identified a new motif involved in the formation of left-handed G-quadruplex DNA and determined the X-ray crystal structure of an LHG4 containing this motif. Structural analysis revealed the importance of split guanines and single thymine loops in promoting LHG4 formation.
A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
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