Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 8, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2021.1910474
Keywords
BRCA2; breast cancer; DDX5; DNA-RNA hybrid; double-strand break; homologous recombination; DSB repair
Categories
Funding
- Spanish Association Against Cancer (AECC)
- Fondation ARC (French Cancer Research Association)
- La Ligue Contre le Cancer
- French Breast Cancer Association Ruban Rose
- European Research Council
- Spanish Ministry of Economy and Competitiveness
- European Union (FEDER)
- Fondation ARC
Ask authors/readers for more resources
In a recent report, a new interaction between BRCA2 and DDX5 at DNA breaks has been revealed, promoting unwinding of DNA-RNA hybrids for repair. Interestingly, this interaction is impaired in cells expressing the BRCA2(T207A) missense variant found in breast cancer patients.
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2(T207A) missense variant found in breast cancer patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
