Microrheology of semiflexible filament solutions based on relaxation simulations

We present an efficient computational methodology to obtain the viscoelastic response of dilute solutions of semiflexible filaments. By considering an approach based on the fluctuation-dissipation theorem, we were able to evaluate the dynamical properties of probe particles immersed in solutions of semiflexible filaments from relaxation simulations with a relatively low computational cost and higher precision in comparison to those based on stochastic dynamics. We used a microrheological approach to obtain the complex shear modulus and the complex viscosity of the solution through its compliance which was obtained directly from the dynamical properties of a probe particle attached to an effective medium described by a mesoscopic model, i.e., an effective filament model (EFM). The relaxation simulations were applied to assess the effects of the bending energy on the viscoelasticity of the semiflexible filament solutions, and our methodology was validated by comparing the numerical results to the experimental data on DNA and collagen solutions.

Automated summary

A computational methodology is proposed to obtain the viscoelastic response of dilute solutions of semiflexible filaments, by evaluating the dynamical properties through the fluctuation-dissipation theorem, microrheological approach, and relaxation simulations. The effects of bending energy on viscoelasticity were assessed, and the methodology was validated by comparing numerical results with experimental data on DNA and collagen solutions.