Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 13, Pages 3025-3031Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00128k
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Funding
- Shenzhen Science and Technology Program [KQTD20190929172743294]
- National Natural Science Foundation of China [21535001, 81730051, 81673039, 32071390]
- National Key RAMP
- D Program of China [2018YFA0902600]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026]
- Shenzhen Bay Laboratory [SZBL2019062801004]
- Guangdong Innovative and Entrepreneurial Research Team Program [2019ZT08Y191]
- Tencent Foundation
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Pharmacokinetics plays a critical role in the clinical applicability of nanomaterials. By studying the pharmacokinetics of A/M-Au NPs, it was found that they exhibit appropriate pharmacokinetic profile and high biosafety, paving the way for their potential biomedical applications.
The pharmacokinetics is a critical factor determining the clinical applicability of nanomaterials. Systematic study of the pharmacokinetics of functional nanomaterials is thus significant for promoting their applications. Herein, we take aminophenylboronic acid and mercaptophenylboronic acid-co-modified gold nanoparticles (A/M-Au NPs) with potent and tunable antibacterial activity as an example to study their behaviors in vitro and in vivo. The maximum concentration (C-max, 2 mg L-1), the time to reach the maximum concentration (T-max, 6 h), and the half-life (T-1/2, 12 h) in the plasma of mice reflect appropriate pharmacokinetics of the gold nanoparticles as an ideal nano-antibiotic. Strikingly, the A/M-Au NPs show an extremely high median lethal dose (920 mg kg(-1)), which is about 100 times their effective dose (7.2 mg kg(-1)), suggesting their outstanding biosafety. The adequate pharmacokinetic profile and the high biosafety of the gold nanoparticles pave the way for their potential biomedical applications.
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