Journal
ASIAN JOURNAL OF ANDROLOGY
Volume 23, Issue 2, Pages 211-214Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/aja.aja_38_20
Keywords
azoospermia; cryopreservation; intracytoplasmic sperm injection; microdissection testicular sperm extraction; pregnancy outcomes
Categories
Funding
- National Key Research and Development Projects [2018YFC1003600, 2016YFC1000302, 2017YFC1002001, SQ2018YFC100243]
- Clinical Medicine PlusX Young Scholars Project, Peking University [2102018237]
- Beijing Municipal Natural Science Foundation [7182177]
Ask authors/readers for more resources
This study evaluated the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment using fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). Results showed that fresh testicular sperm yielded higher rates of clinical pregnancy and live birth compared to cryopreserved sperm, suggesting that fresh testicular sperm may produce better ICSI outcomes in NOA patients.
We performed this study to evaluate the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment that used fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). A total of 338 NOA patients with 344 consecutive cycles received treatment in the reproductive medicine center of Peking University Third Hospital in Beijing, China, from January 2014 to December 2017. Fresh oocytes and fresh sperm were used in 222 patients with 234 cycles (Group A). Fresh oocytes and cryopreserved sperm were used in 116 patients with 110 cycles (Group B). We compared patient characteristics, embryonic development, and pregnancy outcomes between Groups A and B. There was no statistical difference in the patient characteristics, and no differences were observed with fertilization or quality embryo rates between Groups A and B. The rates of clinical pregnancy and live birth were both higher for Group A than those for Group B (both P < 0.05). In conclusion, fresh testicular sperm appears to produce better ICSI outcomes than cryopreserved testicular sperm in patients with NOA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available