Journal
CHEMICAL SOCIETY REVIEWS
Volume 50, Issue 2, Pages 898-944Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cs00354a
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Funding
- Auckland Medical Research Foundation
- Health Research Council of New Zealand
- University of Auckland, New Zealand
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The global market for peptide/protein-based therapeutics is growing significantly, but the development of peptide drugs faces challenges that can be addressed through chemical modification. Recently, there has been a renewed interest in using photoinduced radical thiol-ene chemistry as a powerful tool for constructing therapeutic peptides.
While the global market for peptide/protein-based therapeutics is witnessing significant growth, the development of peptide drugs remains challenging due to their Low oral bioavailability, poor membrane permeability, and reduced metabolic stability. However, a toolbox of chemical approaches has been explored for peptide modification to overcome these obstacles. In recent years, there has been a revival of interest in photoinduced radical thiol-ene chemistry as a powerful tool for the construction of therapeutic peptides.
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