Journal
JOURNAL OF MAGNESIUM AND ALLOYS
Volume 9, Issue 1, Pages 281-291Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.jma.2020.09.013
Keywords
Magnesium alloy membrane; Calcium-phosphate coating; Antibacterial; Biodegradable; Guided bone regeneration
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Funding
- National Natural Science Foundation of China [81600827, U1804251, 51971134]
- National Key R&D program of China [2016YFC1102103]
- Science and Technology Commission of Shanghai [18441908000]
- Shanghai Jiao Tong University Biomedical Engineering Research Fund [YG2019ZDA02]
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In this study, a biodegradable membrane with guided bone regeneration (GBR) was successfully developed using a Mg-2.0Zn-1.0Gd alloy (wt.%, MZG) membrane with Ca-P coating. The membrane demonstrated enhanced hydrophilicity, good cytocompatibility, excellent antibacterial effect, and improved new bone formation, indicating great potential for clinical application as GBR membranes.
To develop a biodegradable membrane with guided bone regeneration (GBR), a Mg-2.0Zn-1.0Gd alloy (wt.%, MZG) membrane with Ca-P coating was designed and fabricated in this study. The microstructure, hydrophilicity, in vitro degradation, cytotoxicity, antibacterial effect and in vivo regenerative performance for the membrane with and without Ca-P coating were evaluated. After coating, the membrane exhibited an enhance hydrophilicity and corrosion resistance, showed good in vitro cytocompatibility upon MC3T3E-1 cells, and exhibited excellent antibacterial effect against E. coli, Staphylococcus epidermis and Staphylococcus aureus, simultaneously. In vivo experiment using the rabbit calvarial defect model confirmed that Ca-P coated MZG membrane underwent progressive degradation without inflammatory reaction and significantly improved the new bone formation at both 1.5 and 3 months after the surgery. All the results strongly indicate that MZG with Ca-P coating have great potential for clinical application as GBR membranes. (C) 2020 Published by Elsevier B.V. on behalf of Chongqing University.
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