Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 34, Pages 4071-4088Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00596k
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- New Jersey Institute of Technology
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This review article presents the most significant developments in the field of tetrasubstituted alkenes from 2007 to 2020, focusing on mechanisms and remaining limitations of contemporary methods, including internal alkyne carbofunctionalizations, multicomponent couplings, and other cross-coupling reactions.
Alkenes bearing four carbon-based groups are ubiquitous motifs in chemical sciences due to their various applications from medicinal to materials chemistry, and as chemical platforms for the synthesis of complex, chiral molecules. As such, tremendous research efforts are currently ongoing in order to develop general procedures for the challenging stereoselective synthesis of all-carbon tetrasubstituted alkenes, especially for acyclic structures. Since classical approaches to carbon-carbon double bonds are not suitable for the high steric demand around tetrasubstituted alkenes, a variety of unique approaches to access these privileged functional groups have been developed in recent years. This review article highlights the most significant developments in the field from 2007 to 2020, with an emphasis on the mechanisms and remaining limitations of these contemporary methods. Specifically, recent advances in internal alkyne carbofunctionalizations, in multicomponent couplings or other cross-couplings from nucleophilic or electrophilic alkenyl partners, and in the development of miscellaneous methods, are discussed.
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