Journal
THERANOSTICS
Volume 11, Issue 11, Pages 5296-5312Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.55986
Keywords
5-hydroxytryptamine; neuroimmune communication; neurotransmitter; serotonin receptor; serotonergic system
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Funding
- Department of Biotechnology [BT/PR15533/MED/30/1616/2015, BT/PR14156/BRB/10/1515/2016]
- Swarna Jayanti Fellowship from Department of Science and Technology [DST/SJF/LSA-01/2017-18]
- Science and Engineering Research Board, Ministry of Science and Technology, Government of India [EMR/2016/007108]
- Council of Scientific and Industrial Research, Government of India
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Serotonin and its receptors modulate immune cells' phenotype and function, affecting tumor immunity. Understanding this mechanism could improve therapeutic strategies for controlling cancer progression and metastasis.
Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases. The crosstalk between the immune cells and the nervous system through serotonin and its receptors (5-HTRs) in the tumor microenvironment and the secondary lymphoid organs are known to affect cancer pathogenesis. However, the molecular mechanism of - alteration in the phenotype and function of - innate and adaptive immune cells by serotonin is not well explored. In this review, we discuss how serotonin and serotonin receptors modulate the phenotype and function of various immune cells, and how the 5-HT-5-HTR axis modulates antitumor immunity. Understanding how 5-HT and immune signaling are involved in tumor immunity could help improve therapeutic strategies to control cancer progression and metastasis.
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