Journal
FOOD RESEARCH INTERNATIONAL
Volume 101, Issue -, Pages 203-208Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2017.09.002
Keywords
GSK-3; NO-cGMP; UV-B; Isoflavone; Soybean sprouts
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Funding
- National Natural Science Foundation of China [31671862]
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The role of glycogen synthase kinase-3 (GSK-3) in the nitric oxide-guanosine 3',5'-cyclic monophosphate (NO-cGMP)-induced isoflavone production in soybean sprouts was examined. Inhibitors and donors of NO, cGMP, and GSK-3 inhibitor were added to UV-B irradiated sprouts. Results showed that NO, with cGMP, induced the expression of GSK-3 under UV-B radiation. Protein kinase G (PKG) was shown to be involved in NO-cGMP-induced GSK-3 activation. GSK-3 elevated activity and expression levels of chalcone synthase (CHS) and isoflavone synthase (IFS), and increased isoflavone accumulation.
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