Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 26, Pages 3235-3238Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00349f
Keywords
-
Categories
Ask authors/readers for more resources
It was demonstrated that a synthetic ligand NA selectively binding to a 5'-CAG-3'/5'-CAG-3' triad induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. Analysis using capillary electrophoresis and sequencing showed that the d(CAG)(20) template generated shortened nascent strands mainly containing 3-6 CTG units in the presence of NA.
We demonstrated that a synthetic ligand NA, which selectively binds to a 5 '-CAG-3 '/5 '-CAG-3 ' triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophoresis and sequencing analysis revealed that the d(CAG)(20) template gave shortened nascent strands mainly containing 3-6 CTG units in the presence of NA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available