Journal
FOOD & FUNCTION
Volume 12, Issue 6, Pages 2760-2771Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo02702b
Keywords
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Funding
- Tertiary Education Commission - Centre of Research Excellence (CoRE
- Wellington, New Zealand)
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This study found that the dissolution of nHA during in vitro gastric digestion involved a rapid early stage and a slower later stage, with the addition of skim milk significantly retarding the dissolution rate of nHA. However, there was no sign of nHA recrystallization in the intestinal phase. X-ray diffraction analysis showed the breakdown of the crystalline structure of nHA and the formation of potentially new calcium phosphate phases during digestion.
This study investigated the behavior of nano-sized particles of hydroxyapatite (nHA) during dynamic in vitro gastrointestinal digestion, alone or dispersed within skim milk. The dissolution and the structural changes of nHA were investigated by analyzing the dissolution of calcium and using transmission electron microscopy and X-ray diffraction. The dissolution of nHA during gastric digestion involved a rapid early stage and a much slower later stage. It was incomplete by the end of gastric digestion, both with and without milk. However, there was no sign of nHA recrystallization in the intestinal phase. X-ray diffraction analysis of digesta showed the breakdown of the crystalline structure of nHA and the formation of potentially new calcium phosphate phases during digestion. Skim milk formed a structural clot and significantly retarded the dissolution of nHA during gastric digestion. Possible mechanisms leading to the incomplete dissolution of nHA and the matrix effect of milk are discussed.
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